Gram-negative bacteria use the T6SS to eject effectors into prey cells, aided by delivery domains. Recently uncovered by Carobbi et al., a new delivery domain, PIX, allowed the identification of hundreds of new effectors. They are order- and function-specific and exclusively orphan effectors, raising novel questions in the field.
Keywords: FIX; MIX; PIX; RIX; T6SS marker; antieukaryotic; antimicrobial; delivery domain; effectors.
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